he following are epidemics which spread across several continents.
* 165 – 180: Antonine Plague, perhaps smallpox
* 251 – 266: Plague of Cyprian
* 541: the Plague of Justinian[1]
* 1300s: the Black Death
* 1501 – 1587: typhus
* 1732 – 1733: influenza
* 1775 – 1776: influenza
* 1816 – 1826: cholera
* 1829 – 1851: cholera
* 1847 – 1848: influenza
* 1852 – 1860: cholera
* 1855 – 1950s: bubonic plague: Third Pandemic
* 1857 – 1859: influenza
* 1863 – 1875: cholera
* 1889 – 1892: influenza
* 1899 – 1923: cholera
* 1918 – 1920: avian flu: Spanish flu: more people were hospitalized in World War I from this epidemic than wounds. Estimates of the dead range from 20 to 100 million worldwide[2]
* 1960s: cholera called El Tor
* 1980s – present: HIV
* 2009: H1N1 flu (also known as the swine flu)[3]

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